Targeting the Gut Microbiome in Chronic Kidney Disease: Emerging Therapeutic Approaches

Chronic kidney disease (CKD) is closely linked to gut dysbiosis, an imbalance within the intestinal microbial community. This disruption in the gut environment contributes to the accumulation of uremic toxins, drives systemic inflammation, and accelerates renal fibrosis.

To address these pathological pathways, researchers and clinicians are examining interventions designed to restore microbial balance. Strategies focused on targeting the gut microbiota include the use of probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), and traditional Chinese medicine, presenting alternative avenues for managing complications associated with CKD.